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Dacarbazine 200 mg is a chemotherapy medication classified as an alkylating agent. It works by damaging the DNA and RNA of cancer cells, which stops them from growing and multiplying. Key Uses (Indications)As of 2026, it remains a standard treatment for several specific cancers: 

• Malignant Melanoma: Used for skin cancer that has metastasized (spread) to other parts of the body.
• Hodgkin's Lymphoma: Often used in combination with other chemotherapy drugs (e.g., the ABVD regimen).
• Soft Tissue Sarcomas: Used in advanced cases for cancers affecting muscles, tendons, or blood vessels. 

Administration & Storage

• Route: Must be administered intravenously (IV) only by a medical professional.
• Preparation: The 200 mg vial is typically reconstituted with approximately 19.7 mL of sterile water to create a 10 mg/mL solution.
• Storage:
  • Unopened Vials: Store in a refrigerator between 2°C and 8°C and protect from light.
  • Reconstituted Solution: Should generally be used within 8 hours if kept at room temperature or up to 24–72 hours if refrigerated (depending on the specific brand). 

Side Effects

• Gastrointestinal: Nausea and vomiting are very common; doctors often prescribe anti-emetics and may recommend fasting for 4–6 hours before a dose to minimize these effects.
• Hematologic: Decreased white blood cell count (leukopenia) and platelet count (thrombocytopenia), which increase infection and bleeding risks.
• Other: Facial flushing, tingling (paresthesia), hair loss, and flu-like symptoms.
• Skin Sensitivity: Increased risk of severe sunburn; patients should avoid prolonged sun exposure.